Tour Lavoisier, 2ème étage,
Hôpital des Enfants Malades,
149 rue de Sèvres,
75015 Paris,

The IRNEM (Institut Fédératif de Recherche Necker-Enfants Malades) is a federation of 19 research laboratories each evaluated and funded by a French national public research organisation such as INSERM (National institute for health and medical research), CNRS (National center for scientific research) or the University of Paris 5.  The Federation is located on the campus of one of the most important French medical schools linked to a university hospital for adults and children.  This complex of public research laboratories, teaching responsibilities and clinical facilities makes this site one of the largest biomedical research centers in France.

The IRNEM comprises 19 group leaders, a total of 678 people. 300 are involved in basic research, clinical research, and clinical practice. 92 post-doc fellows are doing research on the campus. 216 students are in training. 270 represent technical and administrative staff.

Within the IRNEM the research unit INSERM 781 “Genetics and Epigenetics of Neurometabolic Diseases and Birth Defects" is dedicated to the study of the genetic and environmental mechanisms of several inherited diseases with the ultimate goal of improving the understanding of their mechanisms, their accurate diagnosis, clinical management, prevention and hopefully treatment.

IRNEM receives funding from the French Ministry of Research and from other public and private sources in order to develop core facilities and to strengthen scientific collaboration. The facilities include proteomics (mass spectrometry, ion trap-nanoHPLC and 2D gels), centralized animal facilities capable of housing 25000 mice, confocal microscopy, and cell sorting and flow cytometry. IRNEM continuously supports the installation of new technologies on the campus full time scientific officers and research technicians.